Deadly Beauty - 5 stunning images of malignant tumours
Breast Tumor Microenvironment - This image of a breast cancer tumor and its microenvironment was obtained from a live mouse model using multiphoton microscopy and endogenous fluorescence. That is, the image was obtained without any fluorophores, stains, or dyes, using only the metabolic co-factors of NADH and FAD, which are already inside of cells, along with second harmonic generation to see collagen. This technique has important clinical potential for patients who require label-free imaging, and may lead to more effective diagnoses and treatments. Tumor cells display in cyan, macrophages in red, collagen fibers in green.
Source: National Cancer Institute \ Carbone Cancer Center at the Univ. of Wisconsin
Creator: Joseph Szulczewski, David Inman, Kevin Eliceiri, and Patricia Keely
Colon Cancer Cells - Human colon cancer cells with the cell nuclei stained red and the protein E-cadherin stained green. E-cadherin is a cell adhesion molecule and its loss signals a process known as the epithelial-mesenchymal transition in which cells a cquire the ability to migrate and become invasive.
Source: NCI Center for Cancer Research
Creator: Urbain Weyemi, Christophe E. Redon, William M. Bonner
Mitochondrial Dynamics in Pancreatic Cancer : This image shows mitochondrial staining (red) and nuclear staining (blue) of abnormal pancreatic ducts from a mouse model of human pancreatic ductal carcinoma. Mitochondrial shape changes occur throughout the progression of pancreatic cancer and the machinery that regulates the dynamics of mitochondria may be a promising new therapeutic target in the fight against this disease.
Source: National Cancer Institute \ Univ. of Virginia Cancer Center
Creator: David Kashatus
Lung Cancer Metastasis : This image shows how lung cancer cells invade surrounding tissues and start to spread (metastasis). These lung cancer cells have a mutation of a gene called LKB1 (in green) that promotes invasion. Actin, a cytoskeletal protein, is in red, and the cell nucleus is blue. These H157 lung cancer cells are expressing a GFP-tagged piece of LKB1 to disrupt its normal function. Spheroids of these cells were embedded in a 3-D collagen matrix with cells invading for 24 hours.
Source: National Cancer Institute \ Winship Cancer Institute of Emory University
Creator: Scott Wilkinson, Adam Marcus
Skin Cancer Cells: This image shows the uncontrolled growth of cells in squamous cell carcinoma, the second most common form of skin cancer.
Source: The Rockefeller University, New York, N.Y.
Creator: Markus Schober and Elaine Fuchs