Pathology Cartoon - Mr Cranky from Canada

Dr Sampurna Roy MD


Cronkhite-Canada syndrome:


Cronkhite-Canada syndrome is a rare disease characterised by diffuse polyposis of the gastrointestinal tract, diarrhoea, weight loss, abdominal pain, cutaneous hyperpigmentation, dystrophic changes of fingernails, and alopecia.

The etiology is probably autoimmune and diagnosis is based on history, physical examination, endoscopic findings of gastrointestinal polyposis, and histology.

The disease is very rare.

The histological specimens from stomach and small and large intestines show typical features of benign juvenile-like or hamartomatous polyps, mild infiltration of inflammatory cells including eosinophils, massive submucosal edema mostly located in the lamina propria, hyperplasia of the foveolar epithelium, focal hyperplastic features, and cystic dilation of the mucosal glands. In approximately half of the patients, some polyps reveal adenomatous changes with stromal edema and dilated glands.


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