Pathology Poster - Canalicular Adenoma

Dr Sampurna Roy MD

Canalicular Adenoma Poster

Canalicular adenoma is a rare benign salivary gland tumour usually noted in elderly patients. The upper lip is commonly affected.

 Microscopic features:

- Well circumscribed, lobulated tumour with well developed fibrous connective tissue capsule.

- Monotonous population of cuboidal to columnar cells, 1–2 cell layers thick arranged in anastomosing, branching or budding cords, tubules, rows, strands, columns or canaliculi.

- Typical low power appearance - Tramtrack- like double rows of cells that run in parallel, merge at some knots. This is known as the characteristic "beading" phenomenon. 

- These rows of cells part in other areas to form narrow lumen or cystic spaces.

- Luminal squamous balls are present

- The stroma is loose with many capillaries.

- Pleomorphism and mitoses are not seen.

- Immunohistochemistry: The tumour cells are positive for cytokeratin, S100 protein, GFAP and SOX10.


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