Pathology Poster - Canalicular Adenoma
Dr Sampurna Roy MD
Canalicular adenoma is a rare benign salivary gland tumour usually noted in elderly patients. The upper lip is commonly affected.
- Well circumscribed, lobulated tumour with well developed fibrous connective tissue capsule.
- Monotonous population of cuboidal to columnar cells, 1–2 cell layers thick arranged in anastomosing, branching or budding cords, tubules, rows, strands, columns or canaliculi.
- Typical low power appearance - Tramtrack- like double rows of cells that run in parallel, merge at some knots. This is known as the characteristic "beading" phenomenon.
- These rows of cells part in other areas to form narrow lumen or cystic spaces.
- Luminal squamous balls are present
- The stroma is loose with many capillaries.
- Pleomorphism and mitoses are not seen.
- Immunohistochemistry: The tumour cells are positive for cytokeratin, S100 protein, GFAP and SOX10.