Pathology Poster - Juxtaglomerular cell tumour

Dr Sampurna Roy MD

The tumour characterized by hypertension, hyperaldosteronism and hypokalemia secondary to excessive renin secretion by tumour cells

Juxtaglomerular cell tumor

Diagram showing main complications of persistent high blood pressure:

Complications of Blood Pressure



Juxtaglomerular cell tumour ( also known as reninoma) is a rare renal tumour.

The main clinical manifestation is hypertension with excessive renin secretion.

It was first described by Robertson et al. in 1967 and the name was coined by Kihara in 1968.

This tumour usually affects adolescents and young adults.

Gross features: The tumour is well circumscribed with fibrous capsule.

The cut surface has a yellow or gray-tan colour with areas of hemorrhage.

Microscopic features: The tumour is composed of monotonous polygonal cells with entrapped normal tubules.

Immunohistochemically, tumour cells demostrate a positive reactivity for renin, vimentin and CD34.  

Electron microscope : The neoplastic cells contain rhomboid-shaped renin protogranules.

Differential Diagnosis: Glomus tumor, hemangiopericytoma, metanephric adenoma, papillary RCC, collecting duct carcinoma , urothelial carcinoma , renal epithelioid angiomyolipoma and Wilms tumor should be considered.

Approximately 5% of patients with hypertension have specific secondary causes.

It is identified after taking medical history and by physical examination, laboratory tests, and image workup.

Secondary hypertension may be caused by several conditions affecting the kidneys, heart, arteries, or the endocrine system.

Examples: Pheocromocytoma, primary hyperadosteronism, renovascular hypertension, chronic pyelonephritis and renal tumors as renin-producing tumors, nephroblastoma, hypernephroma, and renal cell carcinoma.





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