Pathology Poster -  Myxoid 

 Dr Sampurna Roy MD

 What do we mean when we use the word Myxoid in the pathology report?





In 1858, Rudolph Virchow introduced the term “myxoma”  in his book Die Cellular Pathologie. It was used to describe a soft tissue tumour, histologically resembling the structure of the umbilical cord.

This description of myxoma was adopted in the seventh edition of the Medical Lexicon by Robley Dunglison.

He added that “[myxoma] was for the first time described in 1838 by Johannes Müller as Collonema".

Müller used the term collonema (κολλα = glue) for “peculiar gelatinous tumours, consisting of a remarkably soft gelatiniform tissue, which trembles on being touched”.

It has been generally accepted that it was indeed Virchow who introduced myxoma as an entity.

Myxoid changes/areas are recognized in both benign and malignant neoplasms (primarily classified as mesenchymal or epithelial) as well as non-neoplastic (reactive) lesions.



Willems SM, Wiweger M, van Roggen JFG, Hogendoorn PCW. Running GAGs: myxoid matrix in tumor pathology revisited: What’s in it for the pathologist? Virchows Archiv. 2010;456(2):181-192. 



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